How red blood cells affect blood flow and vascular inflammation
Red blood cell released ATP in disturbed blood flow-initiated site specific vascular inflammation and atherosclerosis
This study looks at how red blood cells release a substance called ATP when blood flow changes, which might help us understand why some blood vessels get inflamed and develop problems like atherosclerosis, and it's designed for anyone interested in how blood flow affects heart and vascular health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-10457975 on NIH RePORTER |
What this research studies
This research investigates how red blood cells (RBCs) release ATP in response to changes in blood flow, which may contribute to vascular inflammation and the development of atherosclerosis. By examining the interactions between blood flow dynamics and RBC activity, the study aims to uncover mechanisms that lead to site-specific vulnerabilities in blood vessels. The research employs both experimental models in mice and computational simulations to explore these relationships, focusing on how RBC-released ATP influences endothelial cell function and vascular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for cardiovascular diseases, particularly those with conditions that may lead to disturbed blood flow.
Not a fit: Patients with stable cardiovascular health and no risk factors for atherosclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cardiovascular diseases linked to atherosclerosis.
How similar studies have performed: While the specific approach of examining RBC-released ATP in this context is novel, related studies have shown that blood flow dynamics significantly influence vascular health.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: He, Pingnian — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: He, Pingnian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.