How radiation affects brain cells and glioblastoma recurrence
Official title: Radiation-induced senescence in the brain microenvironment: Implications for glioblastoma recurrence and therapy
Funded at University of Texas Hlth Science Center · NIH-11045693 · Data updated 2026-11-12
This study looks at how radiation therapy affects the brain and might help glioblastoma, a tough type of brain cancer, come back after treatment, with the hope that what we learn can lead to better ways to fight this disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | April 16, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $321,049 |
| NIH project number | 5R01CA246807-05 |
| Project ID | NIH-11045693 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioblastoma who have undergone radiation therapy.
✕Less likely to help
Patients with other types of brain tumors or those who have not received radiation therapy may not benefit from this research.
What this research studies
This research investigates how radiation therapy impacts the brain microenvironment and contributes to the recurrence of glioblastoma, a highly aggressive brain cancer. By studying the effects of radiation on normal brain cells, the researchers aim to understand how these changes may promote tumor growth and resistance to treatment. The approach involves using advanced mouse models to analyze genetic alterations and the development of a specific phenotype in brain cells that may support tumor recurrence. Patients may benefit from insights that could lead to improved therapeutic strategies for glioblastoma.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that reduce glioblastoma recurrence and improve patient outcomes.
How similar studies have gone: Previous research has shown that understanding the tumor microenvironment can lead to significant advancements in cancer treatment, suggesting potential success for this approach.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Burma, Sandeep — University of Texas Hlth Science Center
- Study coordinator: Burma, Sandeep
Related research
Other NIH-funded projects on the same topics.
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This project aims to create a new way to tell if changes on an MRI scan for Glioblastoma patients are new tumor growth or harmless side effects from radiation treatment.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.