How proteins work together at nerve connections in the brain
Official title: Molecular Mechanisms for Co‐Assembly of Endocytic and Exocytic Machineries at a Synapse
Funded at New York University School of Medicine · NIH-10992094 · Data updated 2026-11-12
This study is looking at how a special protein helps organize important parts of nerve cells in the brain that are needed for them to communicate properly, which could help us understand brain disorders better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 1, 2022 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $224,099 |
| NIH project number | 4R00NS129959-03 |
| Project ID | NIH-10992094 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with brain disorders or those at risk for such conditions, as the findings may directly impact their treatment options.
✕Less likely to help
Patients with non-neurological conditions or those not affected by brain disorders may not receive any benefit from this research.
What this research studies
This research investigates the molecular mechanisms that position two critical protein machineries at nerve terminals in the brain, which are essential for effective communication between nerve cells. By focusing on the presynaptic scaffold Liprin-α, the study aims to understand how this protein organizes the active zone and endocytic apparatus, which are vital for synaptic transmission and recovery of neurotransmitter vesicles. The research employs advanced biological assays and cell line models to explore the interactions and functions of these proteins, providing insights into their roles in brain disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for brain disorders by enhancing our understanding of synaptic function.
How similar studies have gone: Previous research has shown success in understanding synaptic mechanisms, but this specific focus on Liprin-α and its organizing role is relatively novel.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Emperador Melero, Javier — New York University School of Medicine
- Study coordinator: Emperador Melero, Javier
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.