How platelet-monocyte interactions contribute to heart disease in people with HIV
Role of platelet- monocyte interaction in promoting pro-atherogenic state in HIV-infected individuals
This study is looking at how the way platelets and immune cells called monocytes work together might raise the risk of heart disease in people living with HIV, helping us understand why this happens and how it affects heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10876990 on NIH RePORTER |
What this research studies
This research investigates how interactions between platelets and monocytes may lead to increased heart disease risk in individuals living with HIV. It focuses on understanding the biological mechanisms behind this relationship, particularly how these interactions can promote inflammation and atherosclerosis. By analyzing the molecular networks involved, the study aims to uncover how these cellular interactions contribute to cardiovascular complications in HIV-infected patients. The research employs advanced techniques to model these interactions and their effects on cardiovascular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are at risk for cardiovascular disease.
Not a fit: Patients who are not HIV-infected or those without cardiovascular disease risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cardiovascular disease in HIV-infected individuals.
How similar studies have performed: Previous research has shown a connection between HIV and cardiovascular disease, but this specific approach to studying platelet-monocyte interactions is relatively novel.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Thakar, Juilee — University of Rochester
- Study coordinator: Thakar, Juilee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.