How PFAS chemicals affect cholesterol and heart disease
Official title: PFAS accelerate atherosclerosis through modulation of bile acid metabolism
Funded at Wayne State University · NIH-10658104 · Data updated 2026-11-12
This study is looking at how certain chemicals called PFAS might affect cholesterol levels and lead to heart problems, using a special mouse model that acts like humans, to help find new ways to protect people at risk of heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,644,161 |
| NIH project number | 1R01ES034407-01A1 |
| Project ID | NIH-10658104 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with elevated cholesterol levels or those at risk for atherosclerotic cardiovascular disease.
✕Less likely to help
Patients without cardiovascular risk factors or those not exposed to PFAS may not benefit from this research.
What this research studies
This research investigates the impact of per- and polyfluoroalkyl substances (PFAS) on cholesterol levels and the development of atherosclerosis, a major cardiovascular disease. Using a specific mouse model that mimics human cholesterol profiles, the study aims to understand how PFAS exposure accelerates the buildup of fatty deposits in arteries. By examining the relationship between PFAS, bile acid metabolism, and atherosclerosis, the research seeks to provide insights into the mechanisms that contribute to heart disease. The findings could help identify new risk factors and potential interventions for patients at risk of cardiovascular diseases.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of cardiovascular diseases linked to environmental toxins.
How similar studies have gone: While studies have shown PFAS can increase cholesterol in general, this specific approach using a human-like model for atherosclerosis is novel.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Petriello, Michael Curtis — Wayne State University
- Study coordinator: Petriello, Michael Curtis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.