How oxidative stress affects cancer risk and survival over time
Time-dependent and bidirectional effect of oxidative stress - a missing piece of the free radical theory of cancer and its potential implications
This study is looking at how oxidative stress affects cancer over time and why taking antioxidant supplements hasn’t always helped people as expected; it’s for cancer survivors who want to understand how these factors might influence their recovery and health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10993164 on NIH RePORTER |
What this research studies
This research investigates the complex relationship between oxidative stress and cancer, particularly focusing on how its effects can change over time. It aims to understand why antioxidant supplements, which are thought to reduce cancer risk, have not shown clear benefits in large clinical trials and may even increase risk in some cases. By studying cancer survivors and their experiences with oxidative stress, the research seeks to clarify the role of antioxidants in cancer prognosis and healing. The approach includes molecular epidemiological studies to gather evidence on the bidirectional effects of oxidative stress on cancer risk.
Who could benefit from this research
Good fit: Ideal candidates for this research include cancer survivors who have used or are considering antioxidant supplements.
Not a fit: Patients currently undergoing active cancer treatment or those without a history of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights that improve cancer treatment and survivorship care by clarifying the role of oxidative stress and antioxidants.
How similar studies have performed: Previous research has shown mixed results regarding antioxidants and cancer risk, indicating that this area is still under investigation and may lead to novel insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Yang, Gong — Vanderbilt University Medical Center
- Study coordinator: Yang, Gong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.