How nucleic acids influence protein folding and aggregation
Nucleic Acids Roles in Protein Folding and Aggregation
This study is looking at how certain molecules called nucleic acids can help proteins fold correctly and avoid clumping together, which is important for understanding and potentially treating diseases like Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Denver (Colorado Seminary) NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project ID | NIH-10932852 on NIH RePORTER |
What this research studies
This research investigates the role of nucleic acids in the processes of protein folding and aggregation, which are critical in the development of diseases like Alzheimer's. The team is exploring how nucleic acids can act as chaperones to prevent protein misfolding and aggregation. By utilizing a combination of molecular biology, biochemistry, biophysics, and bacterial genetics, the researchers aim to uncover the mechanisms by which nucleic acids influence protein homeostasis. Their findings could lead to new insights into the treatment of neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with neurodegenerative diseases, particularly Alzheimer's disease.
Not a fit: Patients with non-neurodegenerative conditions or those not affected by protein misfolding disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating neurodegenerative diseases such as Alzheimer's.
How similar studies have performed: Previous research has shown promising results in understanding the role of nucleic acids in protein aggregation, indicating that this approach has potential for success.
Where this research is happening
Denver, United States
- University of Denver (Colorado Seminary) — Denver, United States (Active)
Researchers
- Principal investigator: Horowitz, Scott Andrew — University of Denver (Colorado Seminary)
- Study coordinator: Horowitz, Scott Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.