How neurons develop and strengthen communication points in the brain
Molecular and Cellular Mechanisms Mediating Structural and Functional Active Zone Maturation
This study is looking at how brain cells grow and improve their connections to communicate better, which could help us understand brain disorders that affect these connections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11017839 on NIH RePORTER |
What this research studies
This research investigates the processes by which neurons mature their active zones, which are critical for effective synaptic communication. By examining the structural and functional changes that occur at these sites, the study aims to uncover the molecular mechanisms that enhance synaptic strength over time. The research employs advanced experimental techniques to analyze the role of specific proteins in this maturation process, providing insights into how synaptic diversity is achieved. Patients may benefit from a better understanding of brain disorders linked to synaptic dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals with neurological conditions that affect synaptic function.
Not a fit: Patients with non-neurological conditions or those whose symptoms are not related to synaptic communication may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating brain disorders associated with synaptic communication failures.
How similar studies have performed: Previous research has shown promising results in understanding synaptic mechanisms, indicating that this approach has the potential for significant findings.
Where this research is happening
Cambridge, United States
- Massachusetts Institute of Technology — Cambridge, United States (Active)
Researchers
- Principal investigator: Littleton, J. Troy — Massachusetts Institute of Technology
- Study coordinator: Littleton, J. Troy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.