How nerve signals affect bone healing
Official title: CGRP-CLR mediated regulation of bone healing
Funded at University of Connecticut Sch of Med/dnt · NIH-11014388 · Data updated 2026-11-12
This study is looking at how signals from nerves help bones heal after a fracture, especially focusing on a special layer around the bone called the periosteum, and it aims to find out if blocking certain nerve signals can improve the healing process, which could lead to better treatments for people with broken bones.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | April 5, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $397,849 |
| NIH project number | 5R01AR081631-03 |
| Project ID | NIH-11014388 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with recent bone fractures who may benefit from enhanced healing strategies.
✕Less likely to help
Patients with non-fracture related bone conditions or those who do not have sensory nerve involvement in their healing process may not benefit from this research.
What this research studies
This research investigates the role of sensory nerve signals in the process of bone healing, particularly focusing on the periosteum, which is crucial for fracture recovery. The study aims to understand how these nerve signals, specifically through the calcitonin gene-related peptide (CGRP) and its receptor, influence the activation of stem and progenitor cells necessary for forming new bone tissue. By evaluating the effects of CGRP inhibitors on bone healing, the research seeks to uncover the mechanisms behind nerve involvement in the healing process. This could lead to new therapeutic strategies for enhancing bone repair.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bone fractures, enhancing healing and recovery times for patients.
How similar studies have gone: Other research has shown promising results in understanding the role of nerve signals in bone healing, suggesting that this approach could lead to significant advancements.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Kalajzic, Ivo — University of Connecticut Sch of Med/dnt
- Study coordinator: Kalajzic, Ivo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.