How nanoparticle exposure affects inflammation in people with metabolic syndrome
Compromised Resolution of Inflammation following Nanoparticle Exposure in Metabolic Syndrome
['FUNDING_R01'] · PURDUE UNIVERSITY · NIH-11017728
This study looks at how people with metabolic syndrome react to tiny particles from pollution that can cause long-lasting inflammation, and it aims to find ways to help improve their health by understanding how these particles affect the body's natural healing processes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PURDUE UNIVERSITY (nih funded) |
| Locations | 1 site (WEST LAFAYETTE, UNITED STATES) |
| Trial ID | NIH-11017728 on ClinicalTrials.gov |
What this research studies
This research investigates how individuals with metabolic syndrome experience prolonged inflammation when exposed to nanoparticles found in environmental pollutants. It focuses on understanding the mechanisms behind this enhanced inflammatory response, particularly how these nanoparticles interact with the body's signaling pathways. The study aims to identify the role of specialized mediators that help resolve inflammation and how metabolic syndrome disrupts these processes. By examining these interactions, the research seeks to uncover potential therapeutic targets for improving health outcomes in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with metabolic syndrome who are exposed to environmental pollutants.
Not a fit: Patients without metabolic syndrome or those not exposed to environmental nanoparticles may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help manage inflammation in patients with metabolic syndrome, potentially improving their overall health.
How similar studies have performed: Previous research has shown that understanding the inflammatory response in chronic diseases can lead to significant advancements in treatment, suggesting that this approach may yield valuable insights.
Where this research is happening
WEST LAFAYETTE, UNITED STATES
- PURDUE UNIVERSITY — WEST LAFAYETTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHANNAHAN, JONATHAN HENRY — PURDUE UNIVERSITY
- Study coordinator: SHANNAHAN, JONATHAN HENRY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Chronic Disease, chronic disorder