How myeloid cell clusters affect the immune response against tumors
Impact of Circulating Myeloid Cell Clusters on Anti-Tumor Immunity
This study is looking at how certain groups of immune cells in the blood might be making it harder for the body to fight cancer, and it's for cancer patients who want to know more about new ways to improve their treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roswell Park Cancer Institute Corp NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project ID | NIH-11001960 on NIH RePORTER |
What this research studies
This research investigates the role of circulating myeloid cell clusters in suppressing the immune system's ability to fight tumors. It focuses on understanding how these clusters inhibit the function of T cells, which are crucial for anti-tumor immunity. By studying blood samples from cancer patients and animal models, the researchers aim to uncover mechanisms that could lead to new treatment strategies targeting these clusters. The goal is to identify potential drug targets that could enhance the effectiveness of existing cancer therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with advanced solid tumors who are undergoing immunotherapy treatments.
Not a fit: Patients with early-stage cancers or those not receiving immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve the immune response in cancer patients, potentially enhancing the effectiveness of current treatments.
How similar studies have performed: Previous research has shown that targeting myeloid-derived suppressor cells can improve anti-tumor immunity, suggesting that this approach has potential for success.
Where this research is happening
Buffalo, United States
- Roswell Park Cancer Institute Corp — Buffalo, United States (Active)
Researchers
- Principal investigator: Evans, Sharon S — Roswell Park Cancer Institute Corp
- Study coordinator: Evans, Sharon S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.