How mutations in histone H4 affect DNA damage repair and skin cancer development
Implication of histone H4 LRS mutations in translesion synthesis and UV mutagenesis
This study is looking at how certain changes in a protein called histone H4 affect the way our cells fix DNA damage from UV light, which could help us understand more about skin cancer, especially melanoma, and how genetics play a role in that risk.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ A&m Col Baton Rouge NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project ID | NIH-10532160 on NIH RePORTER |
What this research studies
This research investigates the role of specific mutations in histone H4 and their impact on a process called translesion synthesis (TLS), which helps cells repair DNA damage caused by ultraviolet (UV) light. By understanding how these mutations influence the ability of specialized DNA polymerases to bypass UV-induced lesions, the study aims to uncover mechanisms that lead to skin cancer, particularly melanoma. The research employs a combination of genetic analysis and biochemical techniques to explore the relationship between chromatin structure and DNA repair processes. Patients may benefit from insights gained about the genetic factors that contribute to skin cancer risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of skin cancer or those who have experienced significant UV exposure.
Not a fit: Patients who do not have a history of skin cancer or significant UV exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for skin cancer, particularly melanoma.
How similar studies have performed: While the specific focus on histone mutations and TLS is relatively novel, previous research has shown that understanding DNA repair mechanisms can lead to significant advancements in cancer treatment.
Where this research is happening
Baton Rouge, United States
- Louisiana State Univ A&m Col Baton Rouge — Baton Rouge, United States (Active)
Researchers
- Principal investigator: Li, Shisheng — Louisiana State Univ A&m Col Baton Rouge
- Study coordinator: Li, Shisheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.