How mitochondrial metabolism affects weight loss
The role of mitochondrial metabolism in weight loss
['FUNDING_CAREER'] · UNIVERSITY OF WASHINGTON · NIH-10900727
This study is looking at how our body's energy factories, called mitochondria, work when people lose weight, especially when their weight loss slows down or stops, to help find better ways to keep the weight off and reduce health risks.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10900727 on ClinicalTrials.gov |
What this research studies
This research investigates how mitochondrial function changes during weight loss, particularly focusing on the plateau phase where weight loss slows down or stops. It aims to understand the biological mechanisms behind this plateau, which may lead to weight regain and increased cardiovascular risk. The study will involve both human participants and mouse models to explore mitochondrial adaptations in immune cells and other tissues during weight loss. By identifying these mechanisms, the research hopes to provide insights into improving weight loss strategies and maintaining weight loss over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with obesity who are attempting to lose weight and may experience a plateau in their weight loss journey.
Not a fit: Patients who are not overweight or obese may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective weight loss strategies that help maintain weight loss and reduce cardiovascular disease risk.
How similar studies have performed: Other research has shown promising results in understanding metabolic adaptations during weight loss, but the specific focus on the plateau phase is relatively novel.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VALENCIA, ANA PATRICIA — UNIVERSITY OF WASHINGTON
- Study coordinator: VALENCIA, ANA PATRICIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease