How mitochondrial function affects brain activity related to obesity
Official title: Regulation of neuronal function by mitochondrial uncoupling
Funded at University of Iowa · NIH-11035128 · Data updated 2026-11-12
This study is looking at a protein in the brain that might help us understand how to better manage weight and obesity, which could lead to new treatments for people struggling with these issues.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | April 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $153,846 |
| NIH project number | 5K01DK133667-03 |
| Project ID | NIH-11035128 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are struggling with obesity or related metabolic diseases.
✕Less likely to help
Patients who are not overweight or do not have metabolic disorders may not receive benefit from this research.
What this research studies
This research investigates the role of a specific protein, uncoupling protein 1 (UCP1), in the brain and its potential impact on obesity and related metabolic diseases. By studying how UCP1 functions in the central nervous system, particularly in the ventromedial hypothalamus, the research aims to uncover new mechanisms that regulate energy balance and weight management. The approach includes examining the metabolic regulation of UCP1 and its effects on energy homeostasis, which could lead to novel therapeutic strategies for obesity. Patients may benefit from insights gained that could inform future treatments for obesity and its associated conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for obesity and related metabolic disorders, improving health outcomes for many patients.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial function in obesity, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Claflin, Kristin — University of Iowa
- Study coordinator: Claflin, Kristin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.