How metabolism affects the function of immune cells in tumors
Metabolic control of regulatory T cell functional identity
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10902096
This study looks at how the environment inside tumors affects special immune cells called regulatory T cells, which help control the immune response, and it aims to find ways to improve cancer treatments by understanding how these cells adapt to tough conditions in tumors.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10902096 on ClinicalTrials.gov |
What this research studies
This research investigates how the metabolic environment within tumors influences the function of regulatory T cells (Tregs), which play a crucial role in immune response. By examining how Tregs adapt to high levels of lactic acid produced by tumors, the study aims to understand the mechanisms that allow these cells to thrive in hostile conditions while suppressing other immune cells. The research utilizes various experimental models to explore the metabolic pathways involved and how they can be targeted for therapeutic purposes. Patients may benefit from insights gained into improving cancer immunotherapies by manipulating Treg metabolism.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include patients with cancer who are undergoing immunotherapy.
Not a fit: Patients with non-cancerous autoimmune conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by enhancing the efficacy of immunotherapies.
How similar studies have performed: Other research has shown promising results in targeting metabolic pathways in immune cells, suggesting that this approach could be effective.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DELGOFFE, GREG M. — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: DELGOFFE, GREG M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases