How metabolism affects the body's ability to clear bacterial infections
Impact of nucleotide metabolism on bacterial clearance
This study is looking at how our body's energy use affects how we fight off infections like pneumonia, especially from tough bacteria, and aims to find new ways to help our immune system get rid of these infections better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10893393 on NIH RePORTER |
What this research studies
This research investigates the role of host metabolism in the body's response to infections, particularly pneumonia. It focuses on how oxidative metabolism in airway cells influences the persistence of harmful bacteria, such as multidrug-resistant ESKAPE pathogens. By understanding these mechanisms, the research aims to develop new therapies that enhance the body's ability to eradicate these infections. The study will explore the regulation of nucleotide metabolism and its impact on inflammation and infection control.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from pneumonia or those at risk of infections caused by multidrug-resistant bacteria.
Not a fit: Patients with infections not related to pneumonia or those who do not have issues with bacterial clearance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve the body's ability to fight off severe bacterial infections, particularly in patients with pneumonia.
How similar studies have performed: Previous research has shown promise in understanding metabolic pathways in infection control, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Riquelme Colet, Sebastian Alejandro — Columbia University Health Sciences
- Study coordinator: Riquelme Colet, Sebastian Alejandro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.