How metabolic syndrome affects brain cells and contributes to Alzheimer's disease
Official title: Metabolic syndrome impairs oligodendrocyte metabolic support of neurons leading to Alzheimer’s disease/Alzheimer’s disease and related dementias
Funded at University of Michigan at Ann Arbor · NIH-10828447 · Data updated 2026-11-12
This study is looking at how problems with metabolism, like those seen in metabolic syndrome, might affect brain cells that support neurons and could lead to memory issues or Alzheimer's disease, with the hope of finding new ways to help improve brain health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $105,727 |
| NIH project number | 5K99AG081390-02 |
| Project ID | NIH-10828447 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who have been diagnosed with metabolic syndrome.
✕Less likely to help
Patients without metabolic syndrome or those who are not at risk for Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the relationship between metabolic syndrome and Alzheimer's disease by focusing on how metabolic dysfunction impacts the support that oligodendrocytes provide to neurons. The study aims to understand the mechanisms through which metabolic syndrome disrupts the metabolic interactions between these supporting cells and neurons, potentially leading to cognitive decline and Alzheimer's disease. By exploring these cellular interactions, the research seeks to identify new targets for intervention that could mitigate the effects of metabolic syndrome on brain health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease in individuals with metabolic syndrome.
How similar studies have gone: Previous research has shown promising results in understanding the role of metabolic factors in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Noureldein, Mohamed Hussein Mohamed — University of Michigan at Ann Arbor
- Study coordinator: Noureldein, Mohamed Hussein Mohamed
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.