How mental health issues affect treatment outcomes for substance use disorders
Official title: Substance Use Treatment Outcomes: Effect of Psychiatric Comorbidity
Funded at Johns Hopkins University · NIH-11030777 · Data updated 2026-11-12
This study is looking at how substance use disorders and mental health issues like anxiety and depression affect each other and how they influence treatment success, so we can find the best ways to help people dealing with both types of challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 15, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $360,250 |
| NIH project number | 5R01DA058008-03 |
| Project ID | NIH-11030777 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with substance use disorders who also experience mood or anxiety disorders.
✕Less likely to help
Patients with substance use disorders who do not have any psychiatric comorbidities may not benefit directly from this research.
What this research studies
This research investigates the relationship between substance use disorders (SUDs) and psychiatric comorbidities, such as mood and anxiety disorders. By analyzing data from over 5,000 patients involved in 20 randomized controlled trials, the study aims to understand how these comorbid conditions influence treatment outcomes for SUDs. The research will utilize advanced statistical methods to combine individual patient data and assess various outcomes, including treatment retention and drug use. This comprehensive approach seeks to identify optimal treatment strategies for patients facing both SUDs and mental health challenges.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for individuals with co-occurring substance use and mental health disorders.
How similar studies have gone: Previous research has shown mixed results regarding the impact of psychiatric comorbidities on substance use treatment outcomes, indicating that this area is still being explored.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Crum, Rosa M. — Johns Hopkins University
- Study coordinator: Crum, Rosa M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.