How mental health issues affect treatment outcomes for substance use disorders

Substance Use Treatment Outcomes: Effect of Psychiatric Comorbidity

NIH-funded research Johns Hopkins University · NIH-11030777

This study is looking at how substance use disorders and mental health issues like anxiety and depression affect each other and how they influence treatment success, so we can find the best ways to help people dealing with both types of challenges.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionJohns Hopkins University NIH-funded
Lab location1 site (Baltimore, United States)
Project IDNIH-11030777 on NIH RePORTER

What this research studies

This research investigates the relationship between substance use disorders (SUDs) and psychiatric comorbidities, such as mood and anxiety disorders. By analyzing data from over 5,000 patients involved in 20 randomized controlled trials, the study aims to understand how these comorbid conditions influence treatment outcomes for SUDs. The research will utilize advanced statistical methods to combine individual patient data and assess various outcomes, including treatment retention and drug use. This comprehensive approach seeks to identify optimal treatment strategies for patients facing both SUDs and mental health challenges.

Who could benefit from this research

Good fit: Ideal candidates for this research include individuals diagnosed with substance use disorders who also experience mood or anxiety disorders.

Not a fit: Patients with substance use disorders who do not have any psychiatric comorbidities may not benefit directly from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved treatment strategies for individuals with co-occurring substance use and mental health disorders.

How similar studies have performed: Previous research has shown mixed results regarding the impact of psychiatric comorbidities on substance use treatment outcomes, indicating that this area is still being explored.

Where this research is happening

Baltimore, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Affective DisordersAnxiety Disorders
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.