How maternal inflammation during pregnancy affects the development of intestinal cells in babies
Effect of fetal exposure to maternal inflammation on offspring Paneth cell development and homeostasis
This study looks at how inflammation in mothers during preterm births might affect the development of important gut cells in their babies, with the goal of finding ways to help protect newborns' gut health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10873834 on NIH RePORTER |
What this research studies
This research investigates the impact of maternal inflammation, particularly during preterm births, on the development of Paneth cells in infants. It focuses on understanding how exposure to inflammatory cytokines, like interleukin-6 (IL-6), can lead to a decrease in these important intestinal cells, which play a crucial role in gut health. By exploring the mechanisms behind this process, the research aims to identify potential interventions that could mitigate the adverse effects of maternal inflammation on newborns' intestinal health. The study employs a combination of laboratory techniques and animal models to elucidate these pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants born preterm who have been exposed to maternal inflammation, particularly those diagnosed with chorioamnionitis.
Not a fit: Patients who are full-term infants or those without any exposure to maternal inflammation during pregnancy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing intestinal injuries in infants exposed to maternal inflammation during pregnancy.
How similar studies have performed: Previous research has shown that understanding the role of inflammatory cytokines in fetal development can lead to significant insights, suggesting that this approach has potential for success.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Mcelroy, Steven James — University of California at Davis
- Study coordinator: Mcelroy, Steven James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.