How maternal immune cells and probiotics affect infant immunity
Official title: Maternal-infant transfer of microbial modified immunity
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11046645 · Data updated 2026-11-12
This study is looking at how a special probiotic called Limosilactobacillus reuteri can help moms pass important immune cells to their babies during pregnancy and breastfeeding, which might help shape the baby's immune system and protect against diseases later on.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | March 1, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $189,150 |
| NIH project number | 5R21AI182934-02 |
| Project ID | NIH-11046645 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns, particularly those at risk for immune-related conditions or those who may benefit from enhanced immune support.
✕Less likely to help
Patients who are older than 4 weeks or those without any immune system concerns may not receive benefit from this research.
What this research studies
This research investigates how immune cells from mothers can transfer to their infants during pregnancy and breastfeeding, potentially influencing the infant's immune system development. It focuses on the role of a specific probiotic, Limosilactobacillus reuteri DSM 17938, which has shown anti-inflammatory effects in various disease models. By studying how these probiotics modify immune responses and interact with maternal and infant leukocytes, the research aims to enhance our understanding of early life immunity and its implications for conditions like autoimmune diseases. The methodology includes using animal models to track immune cell transfer and function.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing infant immunity and preventing autoimmune diseases.
How similar studies have gone: Previous research has shown promising results with probiotics in modifying immune responses, indicating potential for success in this novel approach.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Liu, Yuying — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Liu, Yuying
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.