How maternal challenges affect child brain development in low-resource settings
Maternal adversity, inflammation, and neurodevelopment: How intergenerational processes perpetuate disadvantage in a low-resource setting
['FUNDING_R01'] · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · NIH-10563215
This study is looking at how tough experiences in a mother's childhood, like abuse or neglect, might affect her baby's brain development while she's pregnant, and it involves pregnant women in Brazil to see how these experiences influence their children's growth and mental health over the first two years of life.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10563215 on ClinicalTrials.gov |
What this research studies
This research investigates how adverse childhood experiences (ACEs) in mothers, such as abuse or neglect, impact the neurodevelopment of their children, particularly focusing on prenatal inflammation. The study will enroll pregnant women in Brazil, both with and without a history of ACEs, and follow their children for two years to assess cognitive control development through MRI and behavioral assessments. By examining the biological mechanisms involved, including genetic and epigenetic factors, the research aims to uncover how these maternal experiences can affect the next generation's mental health.
Who could benefit from this research
Good fit: Ideal candidates for participation are pregnant women in Brazil, particularly those with a history of adverse childhood experiences.
Not a fit: Patients who are not pregnant or those outside the specified low-resource settings may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved interventions and support for children at risk of neurodevelopmental issues due to maternal adversity.
How similar studies have performed: Previous research has shown promising results in understanding the impact of maternal adversity on child development, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DUARTE, CRISTIANE S. — NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
- Study coordinator: DUARTE, CRISTIANE S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Mental disorders, Mental health disorders, Psychiatric Disease, Psychiatric Disorder