How macrophages respond to Salmonella infections
Engagement of the macrophage integrated stress response in Salmonella infection
This study looks at how a type of immune cell called macrophages reacts to Salmonella infections, especially the one that causes abdominal typhus, to learn how our bodies can better fight off these infections and find new treatment options.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10988293 on NIH RePORTER |
What this research studies
This research investigates how macrophages, a type of immune cell, respond to infections caused by Salmonella bacteria. It focuses on the integrated stress response (ISR), a signaling pathway that helps cells adapt to stress by altering their functions, such as protein production and inflammation. The study aims to understand how this response affects the body's ability to fight off Salmonella infections, particularly the strain that causes abdominal typhus. By examining the role of specific proteins and amino acids in this process, the research seeks to uncover new insights into bacterial infections and potential treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with Salmonella infections, particularly those with abdominal typhus.
Not a fit: Patients with infections caused by other types of bacteria unrelated to Salmonella may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating infections caused by Salmonella and improving patient outcomes.
How similar studies have performed: Previous research has shown that understanding the immune response to bacterial infections can lead to significant advancements in treatment, suggesting that this approach has potential for success.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: O'riordan, Mary — University of Michigan at Ann Arbor
- Study coordinator: O'riordan, Mary
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.