How lysosomes affect brain cell activity and communication
Lysosomal control of plasma membrane -endoplasmic reticulum membrane contacts regulates neuronal excitability
This study looks at how tiny parts of brain cells called lysosomes help manage cholesterol and calcium levels, which could affect brain health and contribute to Alzheimer's disease, so we can better understand how to help people with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10868443 on NIH RePORTER |
What this research studies
This research investigates the role of lysosomes in regulating communication between cellular membranes in the brain, particularly focusing on how they manage cholesterol transfer and calcium levels. By studying the Niemann Pick C1 cholesterol transporter, the research aims to understand how disruptions in this process can lead to neurodegenerative conditions like Alzheimer's disease. The approach involves examining cellular signaling mechanisms and their impact on neuronal excitability and health. Patients may benefit from insights into how these cellular processes contribute to Alzheimer's and related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related neurodegenerative conditions.
Not a fit: Patients with non-neurodegenerative conditions or those without cognitive impairment may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Alzheimer's disease and other neurodegenerative disorders.
How similar studies have performed: Previous research has shown promising results in understanding lysosomal function and its implications for neurodegenerative diseases, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Dickson, Eamonn James — University of California at Davis
- Study coordinator: Dickson, Eamonn James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.