How lysosomes affect brain cell activity and communication
Official title: Lysosomal control of plasma membrane -endoplasmic reticulum membrane contacts regulates neuronal excitability
Funded at University of California at Davis · NIH-10868443 · Data updated 2026-11-12
This study looks at how tiny parts of brain cells called lysosomes help manage cholesterol and calcium levels, which could affect brain health and contribute to Alzheimer's disease, so we can better understand how to help people with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $402,500 |
| NIH project number | 5R35GM149211-02 |
| Project ID | NIH-10868443 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related neurodegenerative conditions.
✕Less likely to help
Patients with non-neurodegenerative conditions or those without cognitive impairment may not receive benefit from this research.
What this research studies
This research investigates the role of lysosomes in regulating communication between cellular membranes in the brain, particularly focusing on how they manage cholesterol transfer and calcium levels. By studying the Niemann Pick C1 cholesterol transporter, the research aims to understand how disruptions in this process can lead to neurodegenerative conditions like Alzheimer's disease. The approach involves examining cellular signaling mechanisms and their impact on neuronal excitability and health. Patients may benefit from insights into how these cellular processes contribute to Alzheimer's and related disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Alzheimer's disease and other neurodegenerative disorders.
How similar studies have gone: Previous research has shown promising results in understanding lysosomal function and its implications for neurodegenerative diseases, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Dickson, Eamonn James — University of California at Davis
- Study coordinator: Dickson, Eamonn James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.