How liver disease affects brain function in people with HIV
Impact of NAFLD on Metabolic Brain Function via CEST MRI in HIV-Positive Individuals
This study is looking at how non-alcoholic fatty liver disease (NAFLD) might affect brain health in people living with HIV, to see if it could lead to brain injuries or memory problems, using special brain scans to compare those with and without NAFLD.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10916601 on NIH RePORTER |
What this research studies
This research investigates the relationship between non-alcoholic fatty liver disease (NAFLD) and brain health in individuals living with HIV. It aims to understand how NAFLD may lead to increased risks of brain injury and cognitive decline by examining changes in the blood-brain barrier and brain metabolism. Using advanced MRI techniques, the study will compare brain imaging results between those with and without NAFLD to identify potential impacts on brain function. The findings could help clarify the health challenges faced by people living with HIV and inform future treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who have been diagnosed with non-alcoholic fatty liver disease.
Not a fit: Patients without HIV or those who do not have non-alcoholic fatty liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cognitive health in individuals living with HIV who also have liver disease.
How similar studies have performed: While the specific combination of NAFLD and HIV's impact on brain function is less explored, related research has shown that liver disease can affect cognitive health, indicating potential for meaningful insights.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Uddin, Md Nasir — University of Rochester
- Study coordinator: Uddin, Md Nasir
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.