How intestinal lysozyme affects immune responses to gut bacteria
Official title: Intestinal lysozyme controls mucosal immune response to microbiota
Funded at Rutgers the State Univ of Nj Newark · NIH-10640221 · Data updated 2026-11-12
This study is looking at how a protein called lysozyme, which is made by cells in the gut, affects the immune system and gut health, especially for people with conditions like Crohn's disease and ulcerative colitis, to help find better ways to manage these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers the State Univ of Nj Newark NIH-funded |
| Lab location | 1 site (Newark, United States) |
| Project start | July 1, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $358,541 |
| NIH project number | 5R01DK119198-05 |
| Project ID | NIH-10640221 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel diseases such as Crohn's disease or ulcerative colitis.
✕Less likely to help
Patients without any form of inflammatory bowel disease or related gastrointestinal disorders may not benefit from this research.
What this research studies
This research investigates the role of lysozyme, a protein secreted by intestinal cells, in regulating the immune response to gut microbiota. By using mouse models, the study aims to understand how lysozyme deficiency or overproduction impacts gut health and inflammation, particularly in conditions like Crohn's disease and ulcerative colitis. The research seeks to fill a knowledge gap regarding the physiological functions of lysozyme and its implications for inflammatory bowel diseases (IBD). Patients may benefit from insights that could lead to new treatment strategies for managing IBD.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from inflammatory bowel diseases.
How similar studies have gone: Previous research has shown varying roles of lysozyme in gut health, indicating that this area of study has potential but also presents novel challenges.
Where this research is happening
-
Rutgers the State Univ of Nj Newark
Newark, United States Active
Researchers
- Principal investigator: Gao, Nan — Rutgers the State Univ of Nj Newark
- Study coordinator: Gao, Nan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.