How inflammatory lipids affect plague infection
Impact of inflammatory lipids on Yersinia pestis infection
['FUNDING_R01'] · UNIVERSITY OF LOUISVILLE · NIH-10888400
This study is looking at how certain fats in the body affect the immune response when someone gets infected with the plague bacteria, Yersinia pestis, to find new ways to improve treatment for those affected.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF LOUISVILLE (nih funded) |
| Locations | 1 site (LOUISVILLE, UNITED STATES) |
| Trial ID | NIH-10888400 on ClinicalTrials.gov |
What this research studies
This research investigates the role of inflammatory lipids in the infection process of Yersinia pestis, the bacterium responsible for plague. It focuses on understanding how these lipids influence the body's immune response during the early stages of infection. By studying the mechanisms through which Y. pestis inhibits inflammation, the research aims to uncover potential therapeutic strategies to enhance treatment outcomes. The approach involves examining the synthesis of pro-inflammatory eicosanoids and their impact on immune signaling.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals at risk of plague infection or those with a history of severe bacterial infections.
Not a fit: Patients with non-bacterial infections or those not at risk for plague may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for treating plague and potentially other bacterial infections by enhancing the body's inflammatory response.
How similar studies have performed: While the specific role of lipid mediators in plague has not been previously studied, similar approaches in other bacterial infections have shown promising results.
Where this research is happening
LOUISVILLE, UNITED STATES
- UNIVERSITY OF LOUISVILLE — LOUISVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAWRENZ, MATTHEW B — UNIVERSITY OF LOUISVILLE
- Study coordinator: LAWRENZ, MATTHEW B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections