How inflammation during pregnancy affects a baby's gut health
Effect of fetal exposure to maternal inflammation on offspring Paneth cell development and homeostasis
This project explores how inflammation in pregnant mothers might impact their babies' gut development and overall health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11128566 on NIH RePORTER |
What this research studies
Many babies born early are exposed to inflammation during pregnancy, which can affect their health. We know these infants often face higher risks of health problems, especially with their intestines. This project looks at how inflammation, specifically a molecule called IL-6, might harm important gut cells called Paneth cells in babies. By understanding these steps, we hope to find ways to protect babies from intestinal injury and other issues.
Who could benefit from this research
Good fit: This research is relevant for pregnant individuals experiencing inflammation and their infants, particularly those born prematurely.
Not a fit: Patients not experiencing maternal inflammation during pregnancy or those without related infant intestinal issues may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat intestinal problems in babies exposed to inflammation before birth.
How similar studies have performed: Preliminary data from this team and published findings suggest a link between maternal inflammation and infant gut cell loss, indicating a promising direction for this work.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Mcelroy, Steven James — University of California at Davis
- Study coordinator: Mcelroy, Steven James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.