How inflammation affects cholesterol levels in immune cells
Official title: IDO1 regulation of SR-BI and cholesterol homeostasis in macrophages
Funded at University of Texas Arlington · NIH-10731003 · Data updated 2026-11-12
This study is looking at how inflammation affects cholesterol levels in immune cells, which could help us understand better ways to manage cholesterol in people with conditions like heart disease and diabetes.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Arlington NIH-funded |
| Lab location | 1 site (Arlington, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $457,513 |
| NIH project number | 1R15HL170257-01 |
| Project ID | NIH-10731003 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from conditions related to chronic inflammation, such as atherosclerosis, diabetes, or metabolic syndrome.
✕Less likely to help
Patients with acute inflammatory conditions or those not affected by cholesterol metabolism may not receive direct benefits from this research.
What this research studies
This research investigates the role of inflammation in regulating cholesterol levels within macrophages, which are immune cells crucial for maintaining health. The study focuses on how a specific receptor, SR-BI, influences cholesterol metabolism and its potential downregulation during inflammatory responses. By understanding these mechanisms, the research aims to uncover new insights into how chronic inflammation contributes to diseases like atherosclerosis and diabetes. Patients may benefit from findings that could lead to new treatments targeting cholesterol management in inflammatory conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing cholesterol levels and reducing the risk of cardiovascular diseases in patients with chronic inflammation.
How similar studies have gone: Previous research has shown promising results in understanding lipid metabolism in macrophages, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Texas Arlington
Arlington, United States Active
Researchers
- Principal investigator: Mandal, Subhrangsu S — University of Texas Arlington
- Study coordinator: Mandal, Subhrangsu S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.