How infections affect the immune response in the uterus during pregnancy
Mechanisms of Endometrial Innate Immune Responses to Infection and Impact on Placental Interactions
This study looks at how infections can affect the cells in the uterus that are important for a healthy pregnancy, hoping to find ways to better understand and manage early pregnancy losses related to these infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11089993 on NIH RePORTER |
What this research studies
This research investigates how bacterial and viral infections impact the immune responses of the endometrium, which is crucial for a healthy pregnancy. It focuses on endometrial stromal cells (EnSCs) that play a vital role in preparing the uterus for implantation and supporting the placenta. By examining how these cells respond to infections, the study aims to uncover mechanisms that could lead to pregnancy complications. Patients may benefit from insights that could improve understanding and management of early pregnancy losses linked to infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who have experienced spontaneous pregnancy loss or are at risk due to infections.
Not a fit: Patients who have not experienced pregnancy loss or do not have a history of infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for early pregnancy losses associated with infections.
How similar studies have performed: Previous research has shown that understanding immune responses in the endometrium can lead to significant advancements in reproductive health, indicating potential success for this approach.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Tong, Mancy — Yale University
- Study coordinator: Tong, Mancy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.