How infections affect the endometrium and pregnancy outcomes.
Mechanisms of Endometrial Innate Immune Responses to Infection and Impact on Placental Interactions
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-10906856
This study is looking at how infections in early pregnancy can affect the lining of the uterus, which is important for a healthy pregnancy, to help understand why some women might have trouble staying pregnant when they get infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10906856 on ClinicalTrials.gov |
What this research studies
This research investigates how infections during the first trimester can impact the endometrium, which is crucial for successful implantation and pregnancy. It focuses on understanding the responses of endometrial stromal cells to bacterial and viral infections, particularly how these infections may lead to inflammation and affect the interactions between the endometrium and the placenta. By studying these mechanisms, the research aims to uncover why some women experience pregnancy loss due to infections and how these processes can be influenced.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who have experienced spontaneous pregnancy loss during the first trimester, particularly those with a history of uterine infections.
Not a fit: Patients who are not pregnant or those who have not experienced pregnancy loss may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of pregnancy complications related to infections, potentially reducing the rates of early pregnancy loss.
How similar studies have performed: Other research has shown that understanding immune responses in the endometrium can lead to significant insights into pregnancy outcomes, suggesting that this approach has potential for success.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TONG, MANCY — YALE UNIVERSITY
- Study coordinator: TONG, MANCY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections