How individual cancer cells change during progression and spread
Single Cell Analysis Core
['FUNDING_P01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11306073
This project looks at detailed single-cell molecular data to understand how cancer cells switch states and spread so future treatments can be better targeted.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11306073 on ClinicalTrials.gov |
What this research studies
From my perspective as a patient, researchers will collect high-resolution molecular profiles from individual cancer cells (including DNA, RNA, proteins, and other measures) and combine them across experiments. A central Single Cell Analysis Core will provide advanced computational analysis, modeling, and training to help design experiments and interpret complex multi-omic data. The team aims to build models that reveal the 'tipping points' when cells move toward more aggressive or metastatic states and to integrate findings across different tumor types.
Who could benefit from this research
Good fit: Patients with cancers that provide tumor or blood samples for the program (for example certain breast or bone marrow cancers treated at participating sites) could be involved by donating samples.
Not a fit: People without cancer or with tumor types not included in the program, or those not treated at participating centers, would be unlikely to benefit directly from participation.
Why it matters
Potential benefit: If successful, this work could identify early molecular changes that predict progression and suggest new targets or better timing for therapies.
How similar studies have performed: Single-cell and multi-omic approaches have already revealed important cell types and state changes in several cancers, so this work builds on increasingly successful methods.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WU, JIE — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: WU, JIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Advanced Cancer, Cancer Model, CancerModel, Cancers