How impaired RNA editing may lead to inflammation in inflammatory bowel disease
Official title: Impaired cellular RNA editing as a cause of inflammation in inflammatory bowel disease
Funded at Stanford University · NIH-10983676 · Data updated 2026-11-12
This study is looking at how problems with RNA editing might contribute to inflammatory bowel disease (IBD), like Crohn's disease and ulcerative colitis, to help us understand how our genes affect the immune system and find new ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 15, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $429,230 |
| NIH project number | 1R01DK140912-01 |
| Project ID | NIH-10983676 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with inflammatory bowel disease, such as Crohn's disease or ulcerative colitis.
✕Less likely to help
Patients with non-inflammatory bowel conditions or those without genetic susceptibility to IBD may not benefit from this research.
What this research studies
This research investigates the role of impaired RNA editing in the development of inflammatory bowel disease (IBD), which includes conditions like Crohn's disease and ulcerative colitis. The study focuses on understanding how genetic factors influence RNA editing processes that help regulate immune responses. By examining the relationship between long double-stranded RNAs and the ADAR1 protein, which edits these RNAs to prevent inflammation, the research aims to uncover new insights into the mechanisms behind IBD. Patients may benefit from findings that could lead to novel therapeutic strategies targeting RNA editing pathways.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation and improve outcomes for patients with inflammatory bowel disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of RNA editing in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Li, Jin Billy — Stanford University
- Study coordinator: Li, Jin Billy
Related research
Other NIH-funded projects on the same topics.
-
Mitochondrial Talks: How Energy Networks Shape Inflammatory Bowel Disease
Aimed at people with inflammatory bowel disease (IBD), this project explores how tiny cell powerhouses in the gut may go out of balance and contribute to IBD, with the goal of restoring energy and reducing disease symptoms.
-
Mn in inflammatory bowel disease: how manganese and genes may shape gut inflammation
This grant studies how the mineral manganese and a specific gene variant may influence inflammatory bowel disease in people of different ages.
-
AI-Enhanced Virtual Reality CBT to Reduce Anxiety for IBD Patients
A home-based VR and AI-powered cognitive behavioral therapy program is being tested to help people with inflammatory bowel disease feel less anxious and improve their quality of life.
-
Gasdermin-based epithelial function in inflammatory bowel disease
A funding opportunity that explores how gasdermin proteins affect the lining of the gut and may influence inflammatory bowel disease.
-
Intestinal chondroitin sulfate glycosaminoglycans and their role in inflammatory bowel disease
A clinician-scientist mentoring program aims to advance understanding of how intestinal sugar molecules called chondroitin sulfate glycosaminoglycans influence inflammatory bowel disease and patient care.
-
Improving IBD outcomes through community awareness, referrals, and education
A U01 grant will support programs to raise awareness, improve referrals, and educate patients and clinicians about inflammatory bowel disease to improve diagnosis and care.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.