How impaired RNA editing may lead to inflammation in inflammatory bowel disease
Impaired cellular RNA editing as a cause of inflammation in inflammatory bowel disease
This study is looking at how problems with RNA editing might contribute to inflammatory bowel disease (IBD), like Crohn's disease and ulcerative colitis, to help us understand how our genes affect the immune system and find new ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10983676 on NIH RePORTER |
What this research studies
This research investigates the role of impaired RNA editing in the development of inflammatory bowel disease (IBD), which includes conditions like Crohn's disease and ulcerative colitis. The study focuses on understanding how genetic factors influence RNA editing processes that help regulate immune responses. By examining the relationship between long double-stranded RNAs and the ADAR1 protein, which edits these RNAs to prevent inflammation, the research aims to uncover new insights into the mechanisms behind IBD. Patients may benefit from findings that could lead to novel therapeutic strategies targeting RNA editing pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with inflammatory bowel disease, such as Crohn's disease or ulcerative colitis.
Not a fit: Patients with non-inflammatory bowel conditions or those without genetic susceptibility to IBD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation and improve outcomes for patients with inflammatory bowel disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of RNA editing in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Li, Jin Billy — Stanford University
- Study coordinator: Li, Jin Billy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.