How immune cells respond to infections and inflammation
Macrophage Polarization in Response to Infections and Inflammation
This study looks at how immune cells called macrophages react to infections and inflammation, helping us understand how to keep the right balance between fighting off illness and preventing too much inflammation, which can cause problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10898718 on NIH RePORTER |
What this research studies
This research investigates how macrophages, a type of immune cell, change their behavior in response to infections and inflammation. By analyzing gene expression data from human macrophages, the study aims to understand the balance between their pro-inflammatory and anti-inflammatory states. This balance is crucial, as too much inflammation can lead to tissue damage, while too little can contribute to chronic diseases. The research employs advanced computational methods to uncover the complexities of macrophage responses, which could lead to new insights into treating various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from acute or chronic inflammatory diseases, such as arthritis or atherosclerosis.
Not a fit: Patients with non-inflammatory conditions or those not affected by immune response issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to inflammation and immune response, such as chronic diseases and infections.
How similar studies have performed: Previous research has shown promise in understanding macrophage behavior and its implications for disease, indicating that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Ghosh, Pradipta — University of California, San Diego
- Study coordinator: Ghosh, Pradipta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.