How immune cells can be activated to fight brain tumors
Regulation of Macrophage- and Microglia-mediated STING Signaling in Glioblastoma
This study is looking at how certain immune cells in the brain can be boosted to fight glioblastoma, a tough type of brain cancer, especially after treatments like chemotherapy and radiation, and it hopes to find new ways to help patients feel better and live longer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10914797 on NIH RePORTER |
What this research studies
This research investigates the role of immune cells, specifically macrophages and microglia, in glioblastoma, a type of aggressive brain cancer. It focuses on understanding how these cells can be activated by a molecule called cGAMP, which is produced in response to chemotherapy and radiation. The study aims to uncover the mechanisms that suppress the immune response in glioblastoma and how inhibiting a specific protein, PP2A, can enhance the immune response against tumors. By exploring these pathways, the research seeks to develop novel therapeutic strategies to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with glioblastoma who have undergone standard treatments like surgery, chemotherapy, or radiation.
Not a fit: Patients with other types of brain tumors or those who are not eligible for standard glioblastoma treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the body's immune response against glioblastoma, potentially improving survival rates.
How similar studies have performed: Previous research has shown promise in activating immune responses in tumors using similar approaches, indicating potential for success in this area.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Lu, Rongze Olivia — University of California, San Francisco
- Study coordinator: Lu, Rongze Olivia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.