How IL-19 affects blood flow in fat tissue and its role in obesity-related diseases
Regulation of adipose tissue microvascular function by IL19
This study is looking at how a protein called IL-19 affects blood flow and inflammation in fat tissue, especially for people who are overweight or obese, to better understand how these changes can lead to health problems like heart disease and diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10911853 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called IL-19 in regulating blood flow and inflammation in fat tissue, particularly in individuals who are overweight or obese. The study aims to understand how changes in fat tissue can lead to serious health issues like heart disease and diabetes. By examining the microcirculation in fat tissue, researchers hope to uncover the mechanisms that contribute to these conditions and explore potential therapeutic targets. Patients may be involved in studies that assess the effects of IL-19 on their health and metabolic functions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are overweight or obese and may be experiencing related health issues such as insulin resistance or cardiovascular problems.
Not a fit: Patients who are not overweight or obese, or those without any metabolic or cardiovascular conditions, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood flow and reduce inflammation in obese patients, potentially lowering their risk of heart disease and diabetes.
How similar studies have performed: Other research has shown promising results regarding the role of IL-19 in vascular health, suggesting that this approach may lead to significant advancements in understanding obesity-related diseases.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Scalia, Rosario G — Temple Univ of the Commonwealth
- Study coordinator: Scalia, Rosario G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.