How IL-10 and TGF-ß help HIV hide in Tfh cells in lymph nodes
Official title: Defining molecular pathways triggered by IL-10 and TGFb that drive HIV integration and persistence in Tfh cells in lymph nodes
Funded at Feinstein Institute for Medical Research · NIH-11580997 · Data updated 2026-11-12
This project looks at how specific immune signals in lymph nodes may help HIV persist in certain T cells even when ART is working.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | July 5, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $698,011 |
| NIH project number | 7R01AI179476-04 |
| Project ID | NIH-11580997 on NIH RePORTER |
Who could benefit from this research
✓Could help
People living with HIV, particularly those with lymph node involvement and samples available from biobanked tissues or clinical cohorts.
✕Less likely to help
Individuals without access to the defined patient samples or stages of infection described in the study may not directly benefit.
What this research studies
Researchers will study how the immune signals IL-10 and TGF-ß influence the formation of a HIV reservoir in follicular helper T cells within lymph nodes. The work uses patient samples from people at different stages of HIV infection to understand how these signals may increase HIV integration into our cells’ DNA and suppress antiviral defenses. By examining chromatin changes and signaling pathways, the study aims to identify new points where therapies could intervene to reduce or eliminate persistent HIV. The findings could point to strategies that complement ART to limit viral persistence and improve long-term control of the infection.
Why it matters
Potential benefit: If successful, the research could reveal new targets to reduce HIV persistence and improve the effectiveness of antiretroviral therapies.
How similar studies have gone: Previous studies have linked Tfh cells and viral reservoirs to HIV persistence, with newer work exploring cytokine signaling pathways as potential intervention points.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Pereira Ribeiro, Susan — Feinstein Institute for Medical Research
- Study coordinator: Pereira Ribeiro, Susan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.