How hormones affect the function of ACL in growing knees
Role of Hormones on Bundle-Specific ACL Function in the Growing Knee Joint
This study looks at how sex hormones might affect the knee ligament called the ACL in teens and young adults, especially during puberty, to better understand injury risks and treatment options for both boys and girls.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project ID | NIH-11086138 on NIH RePORTER |
What this research studies
This research investigates the role of sex hormones on the anterior cruciate ligament (ACL) function in adolescents and young adults, particularly focusing on how these hormones may influence injury risk and treatment needs. The study examines differences in ACL structure and function between males and females, especially during puberty when hormonal changes occur. By analyzing the relationship between hormone levels and ACL characteristics, the research aims to provide insights that could lead to more personalized treatment approaches for ACL injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research include adolescents and young adults, particularly females aged 12-20, who are at risk for ACL injuries.
Not a fit: Patients who are not in the age range of 12-20 or those who have not experienced ACL injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for ACL injuries, particularly in adolescent girls who are at higher risk.
How similar studies have performed: Previous research has indicated that hormonal influences can affect ligament function, suggesting that this study's approach could yield valuable insights.
Where this research is happening
Raleigh, United States
- North Carolina State University Raleigh — Raleigh, United States (Active)
Researchers
- Principal investigator: Fisher, Matthew B — North Carolina State University Raleigh
- Study coordinator: Fisher, Matthew B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.