How HIV treatment affects gut health and inflammation
Innate immune mechanisms of epithelial barrier disruption during treated HIV and SIV infections
This study is looking at how the immune system affects gut health in people with HIV who are on long-term treatment, aiming to find ways to improve their overall health and manage related issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-10668086 on NIH RePORTER |
What this research studies
This research investigates the immune mechanisms that lead to gut barrier damage in individuals undergoing long-term treatment for HIV. It focuses on understanding how certain immune cells, particularly gdT cells and Innate Lymphoid Cells, contribute to inflammation and intestinal dysfunction in people living with HIV. By studying these processes, the research aims to identify the links between gut health and various chronic diseases that often accompany HIV. The findings could lead to improved strategies for managing these complications in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are receiving antiretroviral therapy and experiencing related health issues.
Not a fit: Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management of gut health and reduced inflammation in patients living with HIV, potentially improving their overall health outcomes.
How similar studies have performed: Other research has shown promising results in understanding immune mechanisms related to gut health in chronic infections, suggesting that this approach could yield valuable insights.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Rout, Namita — Tulane University of Louisiana
- Study coordinator: Rout, Namita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.