How histones cause injury to blood vessel cells in the lungs
Mechanisms of microvascular endothelial cell injury caused by extracellular histones
This study is looking at how certain proteins released during injuries can affect the tiny blood vessels in the lungs, which might help us find new ways to treat lung problems like acute respiratory distress syndrome (ARDS) for patients dealing with severe infections or trauma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10907514 on NIH RePORTER |
What this research studies
This research investigates how extracellular histones, which are released during tissue injury, affect the function of microvascular endothelial cells in the lungs. The study aims to understand the mechanisms by which these histones contribute to increased inflammation and vascular permeability, worsening conditions like acute respiratory distress syndrome (ARDS). By examining the interaction between histones and specific receptors on endothelial cells, the research seeks to uncover new pathways that lead to lung injury and potential therapeutic targets. Patients with conditions that elevate histone levels, such as sepsis or trauma, may benefit from the findings of this research.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients experiencing acute lung injury, sepsis, or severe trauma.
Not a fit: Patients with chronic respiratory conditions unrelated to acute injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that mitigate lung injury and improve outcomes for patients with acute respiratory distress syndrome.
How similar studies have performed: Other research has shown promising results in understanding the role of DAMPs in various inflammatory conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Birukova, Anna — University of Maryland Baltimore
- Study coordinator: Birukova, Anna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.