How histone modifications influence HIV integration into human cells
Official title: HISTONE MODIFICATIONS GUIDING HIV INTEGRATION
Funded at Ohio State University · NIH-10906005 · Data updated 2026-11-12
This study is looking at how the HIV virus connects to our DNA and what helps it do that, which could help us find better ways to treat people living with HIV.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 11, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $236,250 |
| NIH project number | 5R21AI174874-02 |
| Project ID | NIH-10906005 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are seeking innovative treatment options.
✕Less likely to help
Patients who are not infected with HIV or those who are not currently undergoing treatment for HIV may not benefit from this research.
What this research studies
This research investigates the role of histone modifications in guiding the integration of the HIV-1 virus into human DNA. By understanding how the viral genome inserts itself into host chromatin, the study aims to uncover the mechanisms that control HIV gene expression and latency. The approach involves analyzing the interactions between the HIV integrase protein and cellular factors that influence where the virus integrates within the genome. This could lead to new strategies for targeting HIV in infected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for HIV by targeting the integration process, potentially reducing viral load and improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding viral integration mechanisms, suggesting that this approach could yield significant insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Larue, Ross C. — Ohio State University
- Study coordinator: Larue, Ross C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.