How Hippo kinases affect the immune system and response to infections
Regulation of Innate Immunity by the Hippo Kinases
This study is looking at how certain proteins called Hippo kinases help control the immune system's response to bacterial infections, which could lead to better ways to treat infections and autoimmune diseases.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-11093528 on NIH RePORTER |
What this research studies
This research investigates the role of Hippo kinases in regulating the immune response, particularly how they influence cell death and survival during bacterial infections. By using animal models with specific gene knockouts, the study aims to understand how these kinases affect immune gene expression and the body's ability to fight off pathogens like Legionella pneumophila. The research employs biochemical assays to analyze the function of these kinases and their fragments in immune responses, which could lead to new insights into treating infections and autoimmune diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune diseases or those who are immunocompromised due to genetic factors.
Not a fit: Patients with non-infectious conditions or those without any immune system involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for enhancing immune responses against bacterial infections and improving treatments for autoimmune conditions.
How similar studies have performed: Previous research has shown that targeting immune pathways can lead to significant advancements in understanding and treating infections, suggesting that this approach may yield valuable insights.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Lee, Pei-Chung — Wayne State University
- Study coordinator: Lee, Pei-Chung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.