How herpes simplex virus 1 affects immune responses in skin cells
Regulation of the NLRP1 inflammasome by HSV-1
['FUNDING_R01'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-11048277
This study is looking at how the herpes virus interacts with a part of our immune system in skin cells, which could help us understand how our bodies fight off the virus and lead to new ways to treat infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-11048277 on ClinicalTrials.gov |
What this research studies
This research investigates the interaction between herpes simplex virus 1 (HSV-1) and the NLRP1 inflammasome pathway in human skin cells. The study aims to understand how HSV-1 activates and inhibits this immune response mechanism, which is crucial for defending against viral infections. By examining the role of specific proteins and cellular processes, the research seeks to uncover the underlying mechanisms that regulate the NLRP1 inflammasome during HSV-1 infections. This could provide insights into how skin cells respond to viral threats and the potential for developing new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with recurrent herpes simplex virus infections or those experiencing complications related to HSV-1.
Not a fit: Patients who do not have herpes simplex virus infections or related skin conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for skin infections caused by herpes simplex virus and enhance our understanding of immune responses.
How similar studies have performed: Other research has shown promising results in understanding inflammasome pathways in relation to viral infections, indicating that this approach has potential for success.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ORZALLI, MEGAN HORN — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: ORZALLI, MEGAN HORN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacteria infection, bacterial disease, Bacterial Infections