How herpes simplex virus 1 affects immune responses in skin cells
Official title: Regulation of the NLRP1 inflammasome by HSV-1
Funded at Univ of Massachusetts Med Sch Worcester · NIH-11048277 · Data updated 2026-11-12
This study is looking at how the herpes virus interacts with a part of our immune system in skin cells, which could help us understand how our bodies fight off the virus and lead to new ways to treat infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | November 12, 2024 |
| Project end | October 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $658,273 |
| NIH project number | 1R01AI182052-01A1 |
| Project ID | NIH-11048277 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with recurrent herpes simplex virus infections or those experiencing complications related to HSV-1.
✕Less likely to help
Patients who do not have herpes simplex virus infections or related skin conditions may not benefit from this research.
What this research studies
This research investigates the interaction between herpes simplex virus 1 (HSV-1) and the NLRP1 inflammasome pathway in human skin cells. The study aims to understand how HSV-1 activates and inhibits this immune response mechanism, which is crucial for defending against viral infections. By examining the role of specific proteins and cellular processes, the research seeks to uncover the underlying mechanisms that regulate the NLRP1 inflammasome during HSV-1 infections. This could provide insights into how skin cells respond to viral threats and the potential for developing new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for skin infections caused by herpes simplex virus and enhance our understanding of immune responses.
How similar studies have gone: Other research has shown promising results in understanding inflammasome pathways in relation to viral infections, indicating that this approach has potential for success.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Orzalli, Megan Horn — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Orzalli, Megan Horn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.