How heart injury affects sleep through immune responses
Official title: Ischemic cardiac injury regulates sleep through an immune-mediated heart-brain axis
Funded at Icahn School of Medicine at Mount Sinai · NIH-11104127 · Data updated 2026-11-12
This study is looking at how heart injuries can affect your sleep by exploring how the immune system in your heart might change brain activity related to sleep, which could help improve your heart recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 4, 2025 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $843,607 |
| NIH project number | 1R01HL178835-01 |
| Project ID | NIH-11104127 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced ischemic heart events, such as myocardial infarction, and are experiencing sleep disturbances.
✕Less likely to help
Patients without a history of ischemic heart disease or those who do not experience sleep issues may not benefit from this research.
What this research studies
This research investigates the connection between heart injury and sleep regulation, focusing on how immune responses in the heart can influence brain activity related to sleep. The study aims to understand the mechanisms by which ischemic heart events, like myocardial infarction, recruit immune cells to the brain, potentially altering sleep patterns. By using advanced techniques in neuroscience and immunology, researchers will explore how these changes in sleep may aid in heart recovery. Patients may benefit from insights into how their heart health and sleep are interconnected.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving heart recovery by optimizing sleep patterns in patients with cardiovascular issues.
How similar studies have gone: Previous research has shown promising results in understanding the heart-brain connection, but this specific approach exploring the immune-mediated pathways is relatively novel.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Mcalpine, Cameron Stuart — Icahn School of Medicine at Mount Sinai
- Study coordinator: Mcalpine, Cameron Stuart
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.