How gut microbes affect heart and metabolic health
Cardiovascular disease, metabolic syndrome, microbes and metabolites in FHS
['FUNDING_R01'] · BROAD INSTITUTE, INC. · NIH-11013983
This study is looking at how the tiny microbes in our gut might affect our risk of heart and metabolic diseases like type 2 diabetes and obesity, and it’s for people who want to help us understand how these microbes influence our health by sharing some health information and stool samples.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BROAD INSTITUTE, INC. (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-11013983 on ClinicalTrials.gov |
What this research studies
This research investigates the role of gut microbes in the development of cardiometabolic diseases such as type 2 diabetes, obesity, and atherosclerosis. By analyzing data from the Framingham Heart Study, the researchers aim to identify specific microbial genes that influence cholesterol metabolism and, consequently, disease risk. The study will involve collecting clinical data and stool samples to understand how these microbes interact with the host and affect health outcomes. Patients may be asked to provide samples and health information to help uncover these important relationships.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with or at risk for cardiometabolic diseases such as type 2 diabetes and obesity.
Not a fit: Patients who do not have any risk factors for cardiometabolic diseases may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating cardiometabolic diseases by targeting gut microbiota.
How similar studies have performed: Previous research has shown promising results in understanding the link between gut microbiota and metabolic health, indicating that this approach could yield significant insights.
Where this research is happening
CAMBRIDGE, UNITED STATES
- BROAD INSTITUTE, INC. — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XAVIER, RAMNIK J — BROAD INSTITUTE, INC.
- Study coordinator: XAVIER, RAMNIK J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus, Atherosclerotic Cardiovascular Disease, atherosclerotic disease, atherosclerotic vascular disease