How gut microbes affect heart and metabolic diseases
Metaorganismal Endocrinology in Cardiometabolic Disease
This study is looking at how the tiny microbes in our gut affect health issues like obesity and diabetes, especially when we eat high-fat foods, and it hopes to find new ways to help people by targeting these microbes to improve energy use in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10849797 on NIH RePORTER |
What this research studies
This research investigates the role of gut microbes in influencing diseases like obesity, diabetes, cardiovascular disease, and cancer. It focuses on how certain nutrients from high-fat foods are metabolized by these microbes, leading to the production of compounds that may disrupt metabolic processes. By inhibiting specific microbial enzymes, the research aims to protect against metabolic disturbances and improve circadian rhythms related to energy metabolism. Patients may benefit from new therapeutic strategies that target these microbial pathways.
Who could benefit from this research
Good fit: Ideal candidates include individuals with obesity, diabetes, cardiovascular diseases, or those at risk for these conditions.
Not a fit: Patients with conditions unrelated to metabolic or cardiovascular diseases may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for metabolic and cardiovascular diseases by targeting gut microbial enzymes.
How similar studies have performed: Other research has shown promising results in targeting gut microbiota for metabolic health, suggesting potential success for this approach.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Brown, Jonathan Mark — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Brown, Jonathan Mark
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.