How gut bacteria influence blood cell production and clotting
Official title: Megakaryocyte regulation by the gut microbiome
Funded at Weill Medical Coll of Cornell Univ · NIH-11045057 · Data updated 2026-11-12
This study is looking at how the bacteria in your gut might influence the cells that help your blood clot, especially during infections like COVID-19, to find new ways to manage issues with blood clotting.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $651,165 |
| NIH project number | 5R01HL169989-03 |
| Project ID | NIH-11045057 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with severe COVID-19, autoimmune diseases like rheumatoid arthritis or systemic lupus erythematosus, and those experiencing abnormal blood clotting.
✕Less likely to help
Patients who do not have issues related to blood clotting or are not affected by viral infections or autoimmune diseases may not benefit from this research.
What this research studies
This research investigates the relationship between gut microbiome and megakaryocyte function, which is crucial for platelet production and blood clotting. It aims to understand how gut bacteria, particularly those that produce short-chain fatty acids, can affect the differentiation and activity of megakaryocytes, especially during viral infections like COVID-19. By exploring this connection, the research seeks to uncover new mechanisms that could help manage abnormal blood clotting associated with severe infections and autoimmune diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for managing blood clotting disorders in patients with severe infections and autoimmune diseases.
How similar studies have gone: Other research has shown promising results in understanding the gut microbiome's role in immune responses and blood health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Zeng, Melody Y — Weill Medical Coll of Cornell Univ
- Study coordinator: Zeng, Melody Y
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.