How gut bacteria affect lung health and disease
Official title: Impact of gut bacterial metabolites on lung function and disease
Funded at University of California, San Francisco · NIH-11009069 · Data updated 2026-11-12
This study is looking at how the bacteria in your gut might affect your lung health, especially during issues like COVID-19, by exploring how certain gut bacteria can influence lung injury and breathing problems.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $169,020 |
| NIH project number | 5K08HL165106-03 |
| Project ID | NIH-11009069 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing acute lung injury or respiratory distress, particularly those affected by COVID-19.
✕Less likely to help
Patients with chronic lung diseases unrelated to acute lung injury may not benefit from this research.
What this research studies
This research investigates the relationship between gut bacteria and lung function, particularly focusing on how certain gut bacterial metabolites may influence acute lung injury and respiratory distress. The study aims to understand the role of specific gut bacteria, like Bifidobacterium adolescentis, in activating immune responses that can lead to lung damage. By examining the effects of these bacteria and their metabolites on lung tissue, the research seeks to uncover new insights into the mechanisms behind lung diseases, especially in the context of conditions like COVID-19.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating acute lung injuries and respiratory distress syndromes.
How similar studies have gone: Previous research has shown promising results in understanding the microbiome's role in lung health, suggesting that this approach could yield significant insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Upadhyay, Vaibhav — University of California, San Francisco
- Study coordinator: Upadhyay, Vaibhav
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.