How gut bacteria affect kidney disease progression
Official title: Interspecies microbial interactions in CKD
Funded at University of California at Davis · NIH-11083112 · Data updated 2026-11-12
This study is looking at how the bacteria in your gut might affect chronic kidney disease and how certain bacteria could make kidney problems worse, with the hope of finding new ways to help manage the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | May 15, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $689,809 |
| NIH project number | 5R01DK138912-02 |
| Project ID | NIH-11083112 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are diagnosed with chronic kidney disease.
✕Less likely to help
Patients with acute kidney injury or those without chronic kidney disease may not benefit from this research.
What this research studies
This research investigates the relationship between gut microbiota and chronic kidney disease (CKD). It aims to understand how changes in gut bacteria contribute to the progression of CKD by producing harmful substances known as uremic toxins. The study will explore the molecular mechanisms behind these interactions, particularly focusing on a specific group of bacteria that may worsen kidney function. By examining these microbial dynamics, the research seeks to uncover potential new therapeutic targets for managing CKD.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of chronic kidney disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of gut microbiota in various diseases, suggesting that this approach could yield valuable insights into CKD.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Baumler, Andreas J — University of California at Davis
- Study coordinator: Baumler, Andreas J
Related research
Other NIH-funded projects on the same topics.
-
UC Davis IGA Innovation Center
A research center at UC Davis will study gene-edited livestock to improve animal health, safety, and policy through sharing genetic data and findings about genome edits in cattle, pigs, sheep, and goats.
-
Administrative Core of an equitable breast cancer screening program
A national program headed from UC Davis is coordinating several research efforts to improve how breast cancer screening is done in community settings.
-
The role of novelty and surprise in learning for people with Alzheimer’s disease
A study explores how surprising events affect memory and learning in people related to Alzheimer’s disease, using everyday tasks to see how the brain remembers new information.
-
Understanding how distraction affects students and how to measure it better
This grant studies why distracted students, including those with ADHD, struggle in real-life learning and tests a clearer way to measure distraction in everyday settings.
-
California Partnership for Personalized Nutrition
A California clinical center is testing personalized dietary approaches to improve blood sugar and health for adults with diabetes by using big data and AI to tailor meals.
-
Advancing gastric cancer care for Latinos through patient-derived tumor models
Aimed at Latinos with gastric cancer, this project uses patient-derived tumor models to study how cancer biology and treatments work in real tumors.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.