How glutamine affects the development of immune cells called dendritic cells
Role of glutamine metabolism in Dendritic Cell Development
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10914888
This study is looking at how glutamine, a type of nutrient, affects the growth of important immune cells called dendritic cells, which help our body fight off infections and cancer, to find new ways to improve treatments for autoimmune diseases and cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10914888 on ClinicalTrials.gov |
What this research studies
This research investigates the role of glutamine metabolism in the development of dendritic cells, which are crucial for the immune system's ability to recognize and respond to pathogens and cancer. The study focuses on how the availability of glutamine in different tissue environments influences the differentiation of dendritic cells from their precursors. By understanding these metabolic processes, the research aims to uncover new insights into how immune responses can be modulated, potentially leading to improved treatments for autoimmune diseases and cancers.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with autoimmune diseases or cancers who may have altered immune responses.
Not a fit: Patients with stable, non-immune related conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses against infections and tumors.
How similar studies have performed: Other research has shown promising results in understanding immune cell differentiation through metabolic pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HALDAR, MALAY — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: HALDAR, MALAY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases