How genetics influence inflammation after a heart attack
Official title: Genetic modulation of inflammation following myocardial infarction
Funded at Ohio State University · NIH-10905830 · Data updated 2026-11-12
This study is looking at how certain genes might influence the way your body responds to inflammation after a heart attack, especially focusing on special immune cells that help with healing, and we’d love to have patients share their genetic samples to help us learn more about this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $777,277 |
| NIH project number | 1R01HL174049-01 |
| Project ID | NIH-10905830 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently experienced a myocardial infarction and are willing to participate in genetic testing.
✕Less likely to help
Patients who have not had a heart attack or those with pre-existing severe cardiovascular conditions may not benefit from this research.
What this research studies
This research investigates how specific genetic factors affect the inflammatory response following a heart attack. It focuses on a type of immune cell, known as regulatory T cells, which play a crucial role in controlling inflammation and promoting healing. By examining genetic variations that influence the activity of these cells, the study aims to understand their impact on heart recovery. Patients may be involved in providing genetic samples to help identify these relationships.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving heart healing and reducing complications after a heart attack.
How similar studies have gone: Previous research has shown promising results in understanding the role of immune cells in heart healing, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Gumina, Richard J — Ohio State University
- Study coordinator: Gumina, Richard J
Related research
Other NIH-funded projects on the same topics.
-
Anti-inflammatory signaling of a key protein in heart attack recovery
A study in people who have had a heart attack is exploring how a macrophage protein called Tristetraprolin may reduce inflammation and help protect heart tissue.
-
Targeting RIPK3 to reduce heart damage after a heart attack
This grant studies a specific cell-death pathway (RIPK3) to protect the heart after a heart attack, with the goal of reducing damage and improving recovery.
-
mRNA lipid nanoparticles to help heart attack patients grow healthier blood vessels
A heart-attack study tests a new treatment that uses messenger RNA delivery with tiny fat bubbles to promote normal blood vessel growth in damaged heart tissue.
-
Targeted nanotherapy to calm inflammation, grow new blood vessels, and prevent scarring after a heart attack
A new treatment approach uses engineered secretions from immune cells delivered early after a heart attack to reduce inflammation, promote blood vessel growth, and limit scarring to protect heart function.
-
Why heart attacks and strokes affect people differently across places and races
This project follows adults across the U.S. to see how lifelong social and neighborhood factors shape heart attacks, heart failure, and recovery, with attention to Black adults and regions with high disease rates.
-
Real-time multi-lead ECG from wearables to help detect heart attacks early
A new AI-based approach uses everyday wearable sensors to turn simple PPG signals into multi-lead ECG data to monitor for heart attacks in real time, even outside the clinic.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.